In the 2004 film, The Notebook, James Garner watches Gina Rowlands, the love of his life, slip away into the isolation of Alzheimer's disease. Garner's character reflects as Gina Rowlands stares off into the space of her isolated mind:
"The reason it hurts so much to separate is because our souls are connected. Maybe they always have been and will be. Maybe we've lived a thousand lives before this one and in each of them we've found each other. And maybe each time, we've been forced apart for the same reasons. That means that this goodbye is both a goodbye for the past ten thousand years and a prelude to what will come."